|
KMID : 1094020130300030151
|
|
Journal of Veterinary Clinics
2013 Volume.30 No. 3 p.151 ~ p.158
|
|
|
Evaluation of Plasma NT-proBNP Concentration in Dogs with Chronic Mitral Valve Insufficiency
|
|
Lee Seung-Gon
Hyun Chang-Baig
|
|
|
Abstract
|
|
|
|
This study aimed to evaluate the plasma concentration of NT-proBNP in dogs with different stages of heart failure by chronic mitral valve insufficiency (CMVI). Fifty small-breed dogs with CMVI and 7 healthy control dogs without cardiac disease and critical systemic diseases were included in the study population. As a preliminary study, we compared the plasma concentrations of N-terminal pro-brain natriuretic peptide (NT-proBNP) and the echocardiographic parameters between dogs of the International Small Animal Cardiac Health Council (ISACHC) classes. Then, we evaluated the associations between NT-proBNP and echocardiographic parameters. Plasma NT-proBNP levels showed a significant difference among the ISACHC groups. In the comparison between echocardiographic parameters and NT-proBNP, NT-proBNP were found to be associated with left atrium/aorta (LA/AO), early diastolic transmitral flow (E) velocity, late diastolic transmitral flow (A) velocity, end diastolic volume index (EDVI). Our study found plasma NT-proBNP might be useful to predict the disease progression in dogs with CMVI.
|
|
|
KEYWORD
|
|
|
Echocardiography , NT-proBNP , A flow velocity , dogs , CMVI
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|